Endocrine Abstracts

Introduction: Current treatment for SIADH related hyponatremia is unsatisfactory. We describe two cases of effective Tolvaptan use in SIADH related to disseminated cancer.Case 1: Fifty-three year old female with metastatic ovarian carcinoma, vomiting from partial intestinal obstruction, was referred with sodium 121 mmol and normal renal function. She was clinically dry and mildly confused. SIADH was confirmed but urine Na was <10 suggestive of hypovo...

Introduction: While most common aetiologies accounting for hyperthyroidism are straightforward and respond predictably to treatment, a subset provides diagnostic or therapeutic challenge. We report such a case.Case report: A 26-year-old Afro-Caribbean male presented with symptoms of thyrotoxicosis. FT4 was 50 (12–20 pmol/l), FT3 11.5 (3–8 pmol/l) and TSH 5.38 (0.27–4.20 mU/l). He had diffuse non-tender thyromegaly without eye signs. Thyroi...

Introduction: Our adolescent transition diabetes clinic (16–24 years) is run by a multi-disciplinary team (adult and paediatric diabetes consultant, diabetes specialist nurses and a dietician) every 4 months.Aim: Questionnaire survey of patients understanding of their diabetes and satisfaction about the running and set-up of this unique transition clinic.Method: A two-page questionnaire given to patients attending clinic or po...

Introduction: Hyponatremia is common in hospitalised patients and can be due to a number of aetiologies. Investigations and management are often quite varied.Aims: To find out the prevalence, aetiology, investigations and management of hyponatremia in our hospitalised patients over a 2 week period (1 May and 15 May 2011).Methods: Case notes and electronic data assessment of all patients admitted with sodium level <130 mmol/l.</...

To determine our adherence to the Consensus Development Conference on the Management of Asymptomatic Primary Hyperparathyroidism (2002) guidelines, we audited the management of all patients referred to our endocrine unit with the diagnosis of primary hyperparathyroidism during January 2003 to December 2004.Overall 36 patients were referred. 32 were females and the mean age was 64 years.19 patients were Caucasians, 8 were Asians and 9 patients were of Afr...

Colour-Doppler Ultrasonography (CDU) is applied to the study of many thyroid diseases. In the last one semiquantitative (colour-signal) and quantitative (peak flow velocity at inferior thyroid artery) evaluations are considered. Graves’ disease (GD), amiodarone-induced thyrotoxicosis were better characterized, even Hashimoto thyroiditis and De Quervain thyroiditis were studied. We described a case of Silent Thyroiditis (ST), showing the possibility to distinguish it from ...

Ketosis-prone, Jamaica (J) type diabetes is an uncommon form of diabetes described in a sub-population of mainly Afro-Caribbean patients who often present acutely with diabetic ketoacidosis (DKA) but during follow up demonstrate clinical, metabolic, and immunologic features of Type II diabetes. We present such a case.A 37-year old Afro-Caribbean man with a family history of Type II diabetes presented with polyuria, polydipsia and weight loss. He was over...

Introduction: All stages of diabetic nephropathy are independent risk factors for cardiovascular disease in patients with diabetes. Intensive intervention to achieve target glycaemic control, blood pressure and cholesterol can minimise cardiovascular risk, mainly by reducing proteinuria.Aims: To compare two cohorts of patients, group A, attending a nurse-led clinic in addition to the traditional diabetes renal clinic and group B attending the latter only...

Endocrinopathies are amongst the most common complications of thallasaemia, which is a hereditary disorder of haemoglobin synthesis and excessive iron deposition is thought to be the main reason.Our hospital serves a multiethnic population and consequently we see a substantial number of patients with thallasaemia who are screened for endocrine complications. Those found to have endocrine problems are reviewed in our joint thallasaemia-endocrine clinic. B...

Introduction: Type 2 diabetes results from insulin resistance and B-cell failure. Bariatric surgery is an effective therapeutic modality for type 2 diabetes. Indeed, it induces high remission rates through improved insulin sensitivity and secretion. While the critical role of skeletal muscle in glucose homeostasis has long been known, its role as an endocrine organ secreting peptides, called myokines, has recently been identified. Some of these myokines were shown to influence...